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Does health-related quality of life differ between people with relapse onset and progressive onset Multiple Sclerosis?


Ahmad, H and van der Mei, I and Taylor, BVM and Zhao, T and Xia, Q and Palmer, AJ, Does health-related quality of life differ between people with relapse onset and progressive onset Multiple Sclerosis?, Multiple Sclerosis and Related Disorders, 54 pp. 1-8. ISSN 2211-0348 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier B.V.

DOI: doi:10.1016/j.msard.2021.103138


Background: Multiple Sclerosis (MS) can be categorised as relapse onset MS (ROMS) and progressive onset MS (PROMS). We aimed to examine if health-related quality of life (in terms of health state utilities [HSUs] and dimensional scores) differed by onset type, in which health dimensions the differences were most pronounced, and whether these differences remained when stratified by disability severity. Methods: We estimated HSUs and the unique composite 'super-dimension' and 'individual dimension' scores (crude, age, sex, disease duration and disease modifying therapies use adjusted; and stratified by onset type and disability severity) for a sample of 1577 participants in the Australian MS Longitudinal Study, using the Assessment of Quality of Life (AQoL)-8D. Results: Adjusted mean overall HSU of PROMS was 0.55, 0.07 lower than ROMS. Adjusted mean physical and psychosocial super-dimension scores for PROMS were 0.51 and 0.28, 0.07 and 0.06 lower than for ROMS, respectively. For the individual health dimensions, the largest difference was seen in independent living (-0.12), followed by relationships (-0.07), and self-worth (-0.07). Whilst HSUs and dimensional scores were negatively associated with increasing disability severity in both onset types, estimates by disability severity did not differ between the two cohorts. Conclusions: Our study provides a comprehensive assessment of the effects of MS onset type on the overall and disability-severity specific HRQoL scores using a detailed preferentially sensitive AQoL-8D instrument. While overall HRQoL was substantially lower in PROMS than in ROMS, the mean HRQoL values for each disability level did not differ by onset type, indicating that future health economic models can use the same HSU inputs for both onset types.

Item Details

Item Type:Refereed Article
Keywords:health state utilities (HSUs) AQoL-8D, health-related quality of life (HRQoL), Multiple Sclerosis, progressive onset MS, relapse onset MS
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Ahmad, H (Dr Hasnat Ahmad)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
UTAS Author:Taylor, BVM (Professor Bruce Taylor)
UTAS Author:Zhao, T (Dr Ting Zhao)
UTAS Author:Xia, Q (Miss Qing Xia)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:146074
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-08-19
Last Modified:2022-08-23

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