eCite Digital Repository
Targeting renin-angiotensin system against Alzheimer's Disease
Citation
Gebre, AK and Altaye, BM and Atey, T and Tuem, KB and Berhe, DF, Targeting renin-angiotensin system against Alzheimer's Disease, Frontiers in Pharmacology, 9 pp. 1-11. ISSN 1663-9812 (2018) [Refereed Article]
 | PDF (Published version) 590Kb |
Copyright Statement
Copyright © 2018 Gebre, Altaye, Atey, Tuem and Berhe. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
DOI: doi:10.3389/fphar.2018.00440
Abstract
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and fluid balance through a coordinated action of renal, cardiovascular, and central nervous systems. In addition to its hemodynamic regulatory role, RAS involves in many brain activities, including memory acquisition and consolidation. This review has summarized the involvement of RAS in the pathology of Alzheimer's disease (AD), and the outcomes of treatment with RAS inhibitors. We have discussed the effect of brain RAS in the amyloid plaque (Aβ) deposition, oxidative stress, neuroinflammation, and vascular pathology which are directly and indirectly associated with AD. Angiotensin II (AngII) via AT1 receptor is reported to increase brain Aβ level via different mechanisms including increasing amyloid precursor protein (APP) mRNA, β-secretase activity, and presenilin expression. Similarly, it was associated with tau phosphorylation, and reactive oxygen species generation. However, these effects are counterbalanced by Ang II mediated AT2 signaling. The protective effect observed with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) could be as the result of inhibition of Ang II signaling. ARBs also offer additional benefit by shifting the effect of Ang II toward AT2 receptor. To conclude, targeting RAS in the brain may benefit patients with AD though it still requires further in depth understanding.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | ACEI, AD, ARB, RAS, amyloid β, inflammation, oxidative stress, vascular disease |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Clinical pharmacy and pharmacy practice |
| Objective Division: | Manufacturing |
| Objective Group: | Human pharmaceutical products |
| Objective Field: | Human pharmaceutical treatments |
| UTAS Author: | Atey, T (Mr Tesfay Mehari Atey) |
| ID Code: | 146001 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 62 |
| Deposited By: | Pharmacy |
| Deposited On: | 2021-08-17 |
| Last Modified: | 2021-09-08 |
| Downloads: | 22 View Download Statistics |
Repository Staff Only: item control page