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Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Citation

Tsadik, AG and Atey, TM and Nedi, T and Fantahun, B and Feyissa, M, Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, Journal of Diabetes Research pp. 1-7. ISSN 2314-6753 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 Afewerki Gebremeskel Tsadik et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1155/2018/4910962

Abstract

Background: Lipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.

Objective: To assess insulin-induced lipodystrophy and glycemic control.

Methods: A cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.

Result: Out of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.

Conclusion: Findings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.

Item Details

Item Type:Refereed Article
Keywords:pharmacy, clinical pharmacy, pharmacy practice
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Manufacturing
Objective Group:Human pharmaceutical products
Objective Field:Human pharmaceutical treatments
UTAS Author:Atey, TM (Mr Tesfay Atey)
ID Code:145999
Year Published:2018
Web of Science® Times Cited:8
Deposited By:Pharmacy
Deposited On:2021-08-17
Last Modified:2021-10-28
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