Tsadik, AG and Atey, TM and Nedi, T and Fantahun, B and Feyissa, M, Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, Journal of Diabetes Research pp. 1-7. ISSN 2314-6753 (2018) [Refereed Article]
Copyright 2018 Afewerki Gebremeskel Tsadik et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Background: Lipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.
Objective: To assess insulin-induced lipodystrophy and glycemic control.
Methods: A cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.
Result: Out of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.
Conclusion: Findings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.
|Item Type:||Refereed Article|
|Keywords:||pharmacy, clinical pharmacy, pharmacy practice|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Pharmacology and pharmaceutical sciences|
|Research Field:||Clinical pharmacy and pharmacy practice|
|Objective Group:||Human pharmaceutical products|
|Objective Field:||Human pharmaceutical treatments|
|UTAS Author:||Atey, TM (Mr Tesfay Atey)|
|Web of Science® Times Cited:||8|
|Downloads:||2 View Download Statistics|
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