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Immunologic and clinical failure of antiretroviral therapy in people living with human immunodeficiency virus within two years of treatment


Asgedom, SW and Maru, M and Berihun, B and Gidey, K and Niriayo, YL and Atey, T, Immunologic and clinical failure of antiretroviral therapy in people living with human immunodeficiency virus within two years of treatment, BioMed Research International pp. 1-8. ISSN 2314-6141 (2020) [Refereed Article]

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Copyright Statement

Copyright 2020 Solomon Weldegebreal Asgedom et al. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License, ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1155/2020/5474103


Background: Early initiation of highly active antiretroviral therapy (HAART) decreases human immunodeficiency virus- (HIV-) related complications, restores patients' immunity, decreases viral load, and substantially improves quality of life. However, antiretroviral treatment failure considerably impedes the merits of HAART.

Objective: This study is aimed at determining the prevalence of immunologic and clinical antiretroviral treatment failure.

Methods: A cross-sectional study design using clinical and immunologic treatment failure definition was used to conduct the study. Sociodemographic characteristics and clinical features of patients were retrieved from patients' medical registry between the years 2009 and 2015. All patients who fulfilled the inclusion criteria in the study period were studied. Predictors of treatment failure were identified using Kaplan-Meier curves and multivariable Cox regression analysis. Data analysis was done using SPSS version 21 software, and the level of statistical significance was declared at a p value < 0.05.

Results: A total of 770 were studied. The prevalence of treatment failure was 4.5%. The AZT-based regimen (AHR = 16.95, 95% CI: 3.02-95.1, p = 0.001), baseline CD4 count ≥ 301 (AHR = 0.199, 95% CI: 0.05-0.76, p = 0.018), and bedridden during HAART initiation (AHR = 0.131, 95% CI: 0.029-0.596, p = 0.009) were the predictors of treatment failure.

Conclusion: The prevalence of treatment failure was lower with the risk being higher among patients on the AZT-based regimen. On the other hand, the risk of treatment failure was lower among patients who started HAART at baseline CD4 count ≥ 301 and patients who were bedridden during HAART initiation. We recommend further prospective, multicenter cohort studies to be conducted to precisely detect the prevalence of treatment failure using viral load determination in the whole country.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Manufacturing
Objective Group:Human pharmaceutical products
Objective Field:Human pharmaceutical treatments
UTAS Author:Atey, T (Mr Tesfay Mehari Atey)
ID Code:145961
Year Published:2020
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2021-08-13
Last Modified:2021-09-29
Downloads:12 View Download Statistics

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