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Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis

Citation

Wagatsuma, K and Koolhof, IS and Shobugawa, Y and Saito, R, Decreased human respiratory syncytial virus activity during the COVID-19 pandemic in Japan: an ecological time-series analysis, BMC Infectious Diseases, 21, (1) Article 734. ISSN 1471-2334 (2021) [Refereed Article]


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Copyright Statement

The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

DOI: doi:10.1186/s12879-021-06461-5

Abstract

Background: Non-pharmaceutical interventions (NPIs), such as sanitary measures and travel restrictions, aimed at controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may affect the transmission dynamics of human respiratory syncytial virus (HRSV). We aimed to quantify the contribution of the sales of hand hygiene products and the number of international and domestic airline passenger arrivals on HRSV epidemic in Japan.

Methods: The monthly number of HRSV cases per sentinel site (HRSV activity) in 2020 was compared with the average of the corresponding period in the previous 6 years (from January 2014 to December 2020) using a monthly paired t-test. A generalized linear gamma regression model was used to regress the time-series of the monthly HRSV activity against NPI indicators, including sale of hand hygiene products and the number of domestic and international airline passengers, while controlling for meteorological conditions (monthly average temperature and relative humidity) and seasonal variations between years (20142020).

Results: The average number of monthly HRSV case notifications in 2020 decreased by approximately 85% (p < 0.001) compared to those in the preceding 6 years (20142019). For every average 1 billion (approximately 680,000/$9,000,000) spent on hand hygiene products during the current month and 1 month before there was a 0.29% (p = 0.003) decrease in HRSV infections. An increase of average 1000 domestic and international airline passenger arrivals during the previous 12 months was associated with a 3.8  10− 4% (p < 0.001) and 1.2  10− 3% (p < 0.001) increase in the monthly number of HRSV infections, respectively.

Conclusions: This study suggests that there is an association between the decrease in the monthly number of HRSV cases and improved hygiene and sanitary measures and travel restrictions for COVID-19 in Japan, indicating that these public health interventions can contribute to the suppression of HRSV activity. These findings may help in public health policy and decision making.

Item Details

Item Type:Refereed Article
Keywords:COVID-19, SARS-CoV-2, HRSV, NPIs, epidemics
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiological modelling
Objective Division:Health
Objective Group:Provision of health and support services
Objective Field:Health surveillance
UTAS Author:Koolhof, IS (Mr Iain Koolhof)
ID Code:145905
Year Published:2021
Deposited By:Office of the School of Natural Sciences
Deposited On:2021-08-11
Last Modified:2021-09-08
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