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Associations between respiratory and vascular function in early childhood

Citation

Hemstock, EJ and Shao, J and Zhao, B and Hall, GL and Wheeler, AJ and Dharmage, SC and Melody, SM and Dalton, MF and Foong, RE and Williamson, GJ and Chappell, KJ and Abramson, MJ and Negishi, K and Johnston, FH and Zosky, GR, Associations between respiratory and vascular function in early childhood, Respirology pp. 1-7. ISSN 1323-7799 (2021) [Refereed Article]

Copyright Statement

2021 Asian Pacific Society of Respirology

DOI: doi:10.1111/resp.14117

Abstract

Background and objective: The link between respiratory and vascular health is well documented in adult populations. Impaired lung function is consistently associated with thicker arteries and higher incidence of cardiovascular disease. However, there are limited data on this relationship in young children and the studies that exist have focussed on populations at high risk of cardiorespiratory morbidity. We determined if an association exists between respiratory and cardiovascular function in young children and, if so, whether it is confounded by known cardiorespiratory risk factors.

Methods: Respiratory and vascular data from a prospective cohort study established to evaluate the health implications 3 years after coal mine fire smoke exposure in children aged 3–5 years were used. Respiratory function was measured using the forced oscillation technique and included resistance at 5 Hz (R5), reactance at 5 Hz (X5) and area under the reactance curve (AX). Vascular health was measured by carotid intima-media thickness (ultrasound) and pulse wave velocity (arterial tonometry). Regression analyses were used to examine the relationship between the respiratory Z-scores and cardiovascular measures. Subsequent analyses were adjusted for potential confounding by maternal smoking during pregnancy, maternal education and exposure to fine particulate matter <2.5 μm in aerodynamic diameter (PM2.5).

Results: Peripheral lung function (X5 and AX), but not respiratory system resistance (R5), was associated with vascular function. Adjustment for maternal smoking, maternal education and early life exposure to PM2.5 had minimal effect on these associations.

Conclusion: These observations suggest that peripheral lung stiffness is associated with vascular stiffness and that this relationship is established early in life.

Item Details

Item Type:Refereed Article
Keywords:early life, maternal education, particulate matter, respiratory function, smoking, vascular function
Research Division:Biomedical and Clinical Sciences
Research Group:Paediatrics
Research Field:Infant and child health
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Neonatal and child health
UTAS Author:Hemstock, EJ (Miss Emily Hemstock)
UTAS Author:Shao, J (Ms Jingyi Shao)
UTAS Author:Zhao, B (Miss Bing Zhao)
UTAS Author:Wheeler, AJ (Dr Amanda Wheeler)
UTAS Author:Melody, SM (Dr Shannon Melody)
UTAS Author:Dalton, MF (Ms Marita Dalton)
UTAS Author:Williamson, GJ (Dr Grant Williamson)
UTAS Author:Chappell, KJ (Ms Katherine Chappell)
UTAS Author:Negishi, K (Dr Kazuaki Negishi)
UTAS Author:Johnston, FH (Professor Fay Johnston)
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:145714
Year Published:2021
Deposited By:Plant Science
Deposited On:2021-08-03
Last Modified:2021-09-15
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