University of Tasmania
Browse

File(s) not publicly available

Cortical thickness, volume, and surface area in the motoric cognitive risk syndrome

journal contribution
posted on 2023-05-21, 01:05 authored by Blumen, HM, Schwartz, E, Allali, G, Beauchet, O, Michele CallisayaMichele Callisaya, Doi, T, Shimada, H, Srikanth, V, Verghese, J

Background: The motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established.

Objective: To examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image processing/analysis of multiple cohorts.

Methods: Two-hundred MRIs (M age 72.62 years; 47.74�male; 33.17%MCR) from four different cohorts (50 each) were first processed with FreeSurfer 6.0, and then analyzed using multivariate and univariate general linear models with 1,000 bootstrapped samples (n-1; with resampling). All models adjusted for age, sex, education, white matter lesions, total intracranial volume, and study site.

Results: Overall, cortical thickness was lower in individuals with MCR than in those without MCR. There was a trend in the same direction for cortical volume (p=0.051). Regional cortical thickness was also lower among individuals with MCR than individuals without MCR in prefrontal, insular, temporal, and parietal regions.

Conclusion: Cortical atrophy in MCR is pervasive, and include regions previously associated with human locomotion, but also social, cognitive, affective, and motor functions. Cortical atrophy in MCR is easier to detect in cortical thickness than volume and surface area because thickness is more affected by healthy and pathological aging.

History

Publication title

Journal of Alzheimer's Disease

Volume

81

Pagination

651-665

ISSN

1387-2877

Department/School

Menzies Institute for Medical Research

Publisher

IOS Press

Place of publication

Netherlands

Repository Status

  • Restricted

Socio-economic Objectives

Health related to ageing

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC