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Implications for microglial sex differences in tau-related neurodegenerative diseases
journal contribution
posted on 2023-05-21, 00:57 authored by Yasmine DoustYasmine Doust, Anna KingAnna King, Jenna ZiebellJenna ZiebellTauopathies are a group of neurodegenerative diseases that involve pathological changes to the tau protein. Neuroinflammation is a commonly reported feature of tauopathies that has been demonstrated to exacerbate tau pathology and, hence, neurodegeneration. Microglia can mediate the inflammatory response in order to maintain brain homeostasis. In the aged brain, microglia are reported to undergo morphological and functional changes, adopting a pro-inflammatory profile and loss of homeostatic functions. Dystrophic and dysfunctional microglia are associated with tau pathology in the healthy and diseased brain which is proposed to contribute to disease development and progression. Microglia have also been recently demonstrated to possess sexually dimorphic roles in the developing, adult and aged brain. The sex differences in microglial functionality suggest that microglia may contribute to tauopathies which may differ between sexes. This review highlights the detrimental loop between age-related microglial changes and tau pathology with implications for microglial sexual dichotomy.
History
Publication title
Neurobiology of AgingVolume
105Pagination
340-348ISSN
0197-4580Department/School
Wicking Dementia Research Education CentrePublisher
Elsevier Science IncPlace of publication
360 Park Ave South, New York, USA, Ny, 10010-1710Rights statement
©2021 Elsevier IncRepository Status
- Restricted