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Implications for microglial sex differences in tau-related neurodegenerative diseases

Citation

Doust, YV and King, AE and Ziebell, JM, Implications for microglial sex differences in tau-related neurodegenerative diseases, Neurobiology of Aging, 105 pp. 340-348. ISSN 0197-4580 (2021) [Refereed Article]


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2021 Elsevier Inc

DOI: doi:10.1016/j.neurobiolaging.2021.03.010

Abstract

Tauopathies are a group of neurodegenerative diseases that involve pathological changes to the tau protein. Neuroinflammation is a commonly reported feature of tauopathies that has been demonstrated to exacerbate tau pathology and, hence, neurodegeneration. Microglia can mediate the inflammatory response in order to maintain brain homeostasis. In the aged brain, microglia are reported to undergo morphological and functional changes, adopting a pro-inflammatory profile and loss of homeostatic functions. Dystrophic and dysfunctional microglia are associated with tau pathology in the healthy and diseased brain which is proposed to contribute to disease development and progression. Microglia have also been recently demonstrated to possess sexually dimorphic roles in the developing, adult and aged brain. The sex differences in microglial functionality suggest that microglia may contribute to tauopathies which may differ between sexes. This review highlights the detrimental loop between age-related microglial changes and tau pathology with implications for microglial sexual dichotomy.

Item Details

Item Type:Refereed Article
Keywords:microglia, ageing, tauopathies, sex, neurodegeneration, neuroinflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Doust, YV (Miss Yasmine Doust)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Ziebell, JM (Dr Jenna Ziebell)
ID Code:145443
Year Published:2021
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-07-21
Last Modified:2021-09-07
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