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Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma

Citation

Singh, J and Thachil, T and Eapen, MS and Lim, A and Sufyan, W and Rawson, R and Duncan, H and De Ieso, P and Sohal, SS, Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma, Molecular and Clinical Oncology, 15 pp. 1-8. ISSN 2049-9450 (2021) [Refereed Article]


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DOI: doi:10.3892/mco.2021.2353

Abstract

Cytokines influence the biological behaviour of prostate cancer (PC) and may influence patient outcome and serve as useful prognostic biomarkers. The aim of the present study was to evaluate cytokine expression levels in prostatic needle biopsy specimens and the association with clinicopathological characteristics of patients with PC. A total of 18 patients with PC who underwent transrectal ultrasound (TRUS) guided prostate biopsy were included in the clinical study. These patients were na´ve to radiotherapy (RT) or androgen deprivation therapy prior to TRUS biopsy and clinical follow up data was collected. Cytokine expression levels were analysed by using immunohistochemistry and Spearman's correlation test was used to determine the correlation between cytokine expression and clinicopathological characteristics. Expression levels of pro‑inflammatory TNF‑α and IL‑6 decreased as Gleason score (GS) increased; however, a statistically significant difference was not detected. A statically significant correlation was observed between needle biopsy specimen and pre‑RT plasma sample expression levels of pro‑inflammatory TNF‑α and IL‑6 (P=0.01 and P=0.05, respectively) and anti‑inflammatory TGF‑β1 (P=0.05). However, further studies are needed to confirm these results using a larger sample size to confirm the prognostic value of pro‑inflammatory TNF‑α and IL‑6 and anti‑inflammatory TGF‑β1 in patients with PC.

Item Details

Item Type:Refereed Article
Keywords:cancer, adenocarcinoma, cytokine, prostate, biopsy, radiation therapy
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Eapen, MS (Mr Mathew Eapen)
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:145359
Year Published:2021
Deposited By:Health Sciences
Deposited On:2021-07-19
Last Modified:2021-07-19
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