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Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net
journal contribution
posted on 2023-05-21, 00:39 authored by Ellie BucherEllie Bucher, Jessica CollinsJessica Collins, Anna KingAnna King, James VickersJames Vickers, Matthew KirkcaldieMatthew KirkcaldieThe calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic domains on principal cells and are extensively interconnected in laminar networks by synapses and gap junctions. Beyond its utility as a convenient cellular marker, parvalbumin is an unambiguous identifier of the key role that these interneurons play in the fundamental functions of the cortex. They provide a temporal framework for principal cell activity by propagating gamma oscillation, providing coherence for cortical information processing and the basis for timing-dependent plasticity processes. As these parvalbumin networks mature, they are physically and functionally stabilised by axonal myelination and development of the extracellular matrix structure termed the perineuronal net. This maturation correlates with the emergence of high-speed, highly energetic activity and provides a coherent foundation for the unique ability of the cortex to cross-correlate activity across sensory modes and internal representations.
Funding
The Yulgilbar Foundation
History
Publication title
Brain structure & FunctionVolume
226Issue
7Pagination
2041-2055ISSN
1863-2653Department/School
Wicking Dementia Research Education CentrePublisher
Springer-VerlagPlace of publication
GermanyRights statement
© Crown 2021Repository Status
- Restricted