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Type-2 Diabetes as a risk factor for severe COVID-19 infection


Norouzi, M and Norouzi, S and Ruggiero, A and Khan, MS and Myers, S and Kavanagh, K and Vemuri, R, Type-2 Diabetes as a risk factor for severe COVID-19 infection, Microorganisms, 9, (6) Article 1211. ISSN 2076-2607 (2021) [Refereed Article]

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Copyright Statement

Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License, ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: doi:10.3390/microorganisms9061211


The current outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed coronavirus disease 2019 (COVID-19), has generated a notable challenge for diabetic patients. Overall, people with diabetes have a higher risk of developing different infectious diseases and demonstrate increased mortality. Type 2 diabetes mellitus (T2DM) is a significant risk factor for COVID-19 progression and its severity, poor prognosis, and increased mortality. How diabetes contributes to COVID-19 severity is unclear; however, it may be correlated with the effects of hyperglycemia on systemic inflammatory responses and immune system dysfunction. Using the envelope spike glycoprotein SARS-CoV-2, COVID-19 binds to angiotensin-converting enzyme 2 (ACE2) receptors, a key protein expressed in metabolic organs and tissues such as pancreatic islets. Therefore, it has been suggested that diabetic patients are more susceptible to severe SARS-CoV-2 infections, as glucose metabolism impairments complicate the pathophysiology of COVID-19 disease in these patients. In this review, we provide insight into the COVID-19 disease complications relevant to diabetes and try to focus on the present data and growing concepts surrounding SARS-CoV-2 infections in T2DM patients.

Item Details

Item Type:Refereed Article
Keywords:diabetes, SARS-CoV-2, immune response, adipose tissue, glucose metabolism, vaccines
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Infectious agents
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Myers, S (Dr Stephen Myers)
UTAS Author:Kavanagh, K (Associate Professor Kylie Kavanagh)
ID Code:145251
Year Published:2021
Web of Science® Times Cited:13
Deposited By:Health Sciences
Deposited On:2021-07-13
Last Modified:2022-12-06
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