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Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

journal contribution
posted on 2023-05-21, 00:28 authored by Radley, JJ, Otto JohnsonOtto Johnson, Janssen, WGM, Martino, J, Lamprecht, R, Hof, PR, LeDoux, JE, Morrison, JH
Changes in dendritic spine number and shape are believed to reflect structural plasticity consequent to learning. Previous studies have strongly suggested that the dorsal subnucleus of the lateral amygdala is an important site of physiological plasticity in Pavlovian fear conditioning. In the present study, we examined the effect of auditory fear conditioning on dendritic spine numbers in the dorsal subnucleus of the lateral amygdala using an immunolabelling procedure to visualize the spine-associated protein spinophilin. Associatively conditioned rats that received paired tone and shock presentations had 35% more total spinophilin-immunoreactive spines than animals that had unpaired stimulation, consistent with the idea that changes in the number of dendritic spines occur during learning and account in part for memory.

History

Publication title

European Journal of Neuroscience

Volume

24

Pagination

876-884

ISSN

0953-816X

Department/School

School of Psychological Sciences

Publisher

Blackwell Publishing Ltd

Place of publication

9600 Garsington Rd, Oxford, England, Oxon, Ox4 2Dg

Rights statement

Copyright The Authors (2006).

Repository Status

  • Restricted

Socio-economic Objectives

Mental health

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