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Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala
Citation
Radley, JJ and Johnson, LR and Janssen, WGM and Martino, J and Lamprecht, R and Hof, PR and LeDoux, JE and Morrison, JH, Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala, European Journal of Neuroscience, 24, (3) pp. 876-884. ISSN 0953-816X (2006) [Refereed Article]
Copyright Statement
Copyright The Authors (2006).
DOI: doi:10.1111/j.1460-9568.2006.04962.x
Abstract
Changes in dendritic spine number and shape are believed to reflect structural plasticity consequent to learning. Previous studies have strongly suggested that the dorsal subnucleus of the lateral amygdala is an important site of physiological plasticity in Pavlovian fear conditioning. In the present study, we examined the effect of auditory fear conditioning on dendritic spine numbers in the dorsal subnucleus of the lateral amygdala using an immunolabelling procedure to visualize the spine-associated protein spinophilin. Associatively conditioned rats that received paired tone and shock presentations had 35% more total spinophilin-immunoreactive spines than animals that had unpaired stimulation, consistent with the idea that changes in the number of dendritic spines occur during learning and account in part for memory.
Item Details
Item Type: | Refereed Article |
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Keywords: | memory, PTSD, Amygdala |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Cellular nervous system |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Mental health |
UTAS Author: | Johnson, LR (Associate Professor Luke Johnson) |
ID Code: | 145140 |
Year Published: | 2006 |
Web of Science® Times Cited: | 38 |
Deposited By: | Psychology |
Deposited On: | 2021-07-02 |
Last Modified: | 2021-10-01 |
Downloads: | 0 |
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