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A recurrent network in the lateral amygdala: a mechanism for coincidence detection
Citation
Johnson, LR and Hou, M and Ponce-Alvarez, A and Gribelyuk, LM and Alphs, HH and Albert Jr, L and Brown, BL and LeDoux, JE and Doyere, V, A recurrent network in the lateral amygdala: a mechanism for coincidence detection, Frontiers in Neural Circuits, 2 pp. 1-19. ISSN 1662-5110 (2008) [Refereed Article]
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Copyright Statement
© 2008 Johnson, Hou, Ponce-Alvarez, Gribelyuk, Alphs, Albert, Brown, LeDoux and Doyère. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
DOI: doi:10.3389/neuro.04.003.2008
Abstract
Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage
of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is
understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic
recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory
afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response
to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network
activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal
coincidence of sensory afferents within LAd during associative learning.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | memory, PTSD, Amygdala |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular nervous system |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Mental health |
| UTAS Author: | Johnson, LR (Associate Professor Luke Johnson) |
| ID Code: | 145137 |
| Year Published: | 2008 |
| Web of Science® Times Cited: | 27 |
| Deposited By: | Psychology |
| Deposited On: | 2021-07-02 |
| Last Modified: | 2021-09-08 |
| Downloads: | 11 View Download Statistics |
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