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A recurrent network in the lateral amygdala: a mechanism for coincidence detection


Johnson, LR and Hou, M and Ponce-Alvarez, A and Gribelyuk, LM and Alphs, HH and Albert Jr, L and Brown, BL and LeDoux, JE and Doyere, V, A recurrent network in the lateral amygdala: a mechanism for coincidence detection, Frontiers in Neural Circuits, 2 pp. 1-19. ISSN 1662-5110 (2008) [Refereed Article]

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Copyright Statement

© 2008 Johnson, Hou, Ponce-Alvarez, Gribelyuk, Alphs, Albert, Brown, LeDoux and Doyère. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

DOI: doi:10.3389/neuro.04.003.2008


Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning.

Item Details

Item Type:Refereed Article
Keywords:memory, PTSD, Amygdala
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Johnson, LR (Associate Professor Luke Johnson)
ID Code:145137
Year Published:2008
Web of Science® Times Cited:27
Deposited By:Psychology
Deposited On:2021-07-02
Last Modified:2021-09-08
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