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Risk factors and prediction models for venous thromboembolism in ambulatory patients with lung cancer

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posted on 2023-05-21, 00:17 authored by Yan, A-R, Samarawickrema, I, Naunton, M, Gregory PetersonGregory Peterson, Yip, D, De Rosa, S, Mortazavi, R
Venous thromboembolism (VTE) is a significant cause of mortality in patients with lung cancer. Despite the availability of a wide range of anticoagulants to help prevent thrombosis, thromboprophylaxis in ambulatory patients is a challenge due to its associated risk of haemorrhage. As a result, anticoagulation is only recommended in patients with a relatively high risk of VTE. Efforts have been made to develop predictive models for VTE risk assessment in cancer patients, but the availability of a reliable predictive model for ambulate patients with lung cancer is unclear. We have analysed the latest information on this topic, with a focus on the lung cancer-related risk factors for VTE, and risk prediction models developed and validated in this group of patients. The existing risk models, such as the Khorana score, the PROTECHT score and the CONKO score, have shown poor performance in external validations, failing to identify many high-risk individuals. Some of the newly developed and updated models may be promising, but their further validation is needed.

History

Publication title

Healthcare

Volume

9

Issue

6

Pagination

1-13

ISSN

2227-9032

Department/School

Tasmanian School of Medicine

Publisher

MDPI AG

Place of publication

Switzerland

Rights statement

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).

Repository Status

  • Open

Socio-economic Objectives

Efficacy of medications; Prevention of human diseases and conditions