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A systematic review of cost-effectiveness analyses of continuous versus intermittent renal replacement therapy in acute kidney injury


Singh, A and Hussain, S and Kher, V and Palmer, AJ and Jose, M and Antony, B, A systematic review of cost-effectiveness analyses of continuous versus intermittent renal replacement therapy in acute kidney injury, Expert Review of Pharmacoeconomics and Outcomes Research pp. 1-9. ISSN 1473-7167 (2021) [Refereed Article]

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2021 Informa UK Limited, trading as Taylor & Francis Group

DOI: doi:10.1080/14737167.2021.1916471


Introduction: Though cost-effectiveness analyses (CEAs) have evaluated continuous renal replacement therapy (RRTs) and intermittent RRTs in acute kidney injury (AKI) patients; it is yet to establish which RRT technique is most cost-effective. We systematically reviewed the current evidence from CEAs of CRRT versus IRRT in patients with AKI.

Areas covered: PubMed, EMBASE, and Cochrane databases searched for CEAs comparing two RRTs. Overall, seven CEAs, two from Brazil and one from US, Canada, Colombia, Belgium, and Argentina were included. Five CEAs used Markov model, three reported following CHEERS, none accounted indirect costs. Time horizon varied from 1-year-lifetime. Marginal QALY gain with CRRT compared to IRRT was reported across CEAs. Older CEAs found CRRT to be costlier and not cost-effective than IRRT (ICER 2019 US$: 152,671$/QALY); latest CEAs (industry-sponsored) reported CRRT to be cost-saving versus IRRT (-117,614$/QALY). Risk of mortality, dialysis dependence, and incidence of renal recovery were the key drivers of cost-effectiveness.

Expert opinion: CEAs of RRTs for AKI show conflicting findings with secular trends. Latest CEAs suggested CRRT to be cost-effective versus IRRT with dialysis dependence rate as major driver of cost-effectiveness. Future CEAs, preferably non-industry sponsored, may account for indirect costs to improve the generalizability of CEAs.

Item Details

Item Type:Refereed Article
Keywords:acute kidney injury, CRRT, IRRT, cost-effectiveness analysis, dialysis, health economics, systematic review
Research Division:Economics
Research Group:Applied economics
Research Field:Health economics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Singh, A (Mr Ambrish Singh)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
UTAS Author:Jose, M (Professor Matthew Jose)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
ID Code:144941
Year Published:2021
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-06-22
Last Modified:2021-10-11

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