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Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers

Citation

Turner, JA and Padgett, C and McDonald, S and Ahuja, KDK and Francis, HM and Lim, CK and Honan, CA, Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers, Brain, Behavior, & Immunity - Health, 14 Article 100254. ISSN 2666-3546 (2021) [Refereed Article]


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DOI: doi:10.1016/j.bbih.2021.100254

Abstract

Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demographically-matched healthy individuals. Additionally, we compared the immune marker profile in serum and urine-matched samples. Social cognitive functioning was objectively assessed using The Awareness of Social Inference Test Short (TASIT-S) and subjectively assessed using self-reports of abilities in emotion recognition, emotional empathy, and cognitive theory of mind. In people with MS and healthy individuals, there were moderate-to-large negative relationships between pro-inflammatory biomarkers (serum IL-1β, IL-17, TNF-α, IP-10, MIP-1α, and urine IP-10, MIP-1β) of the innate immune system and social-cognitive functioning. In MS, a higher serum concentration of the antiinflammatory marker IL-1ra was associated with better social-cognitive functioning (i.e., self-reported emotional empathy and TASIT-S sarcasm detection performance). However, there were mixed findings for anti-inflammatory serum markers IL-4 and IL-10. Overall, our findings indicate a relationship between proinflammatory cytokines and social-cognitive abilities. Future studies may provide greater insight into biologically-derived inflammatory processes, sickness behaviour, and their connection with social cognition.

Item Details

Item Type:Refereed Article
Keywords:multiple sclerosis, social cognition, inflammation, TASIT-S, Theory of Mind, Emotion perception, Sarcasm, Emotional empathy, sickness behaviour, Innate immunity
Research Division:Psychology
Research Group:Biological psychology
Research Field:Biological psychology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Turner, JA (Mr Jason Turner)
UTAS Author:Padgett, C (Dr Christine Padgett)
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Honan, CA (Dr Cynthia Honan)
ID Code:144933
Year Published:2021
Deposited By:Psychology
Deposited On:2021-06-22
Last Modified:2021-06-22
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