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Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function


Fletcher, JL and Makowiecki, K and Cullen, CL and Young, KM, Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function, Seminars in Cell and Developmental Biology ISSN 1084-9521 (2021) [Refereed Article]

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Copyright 2021 the authors

DOI: doi:10.1016/j.semcdb.2021.03.017


During cortical development and throughout adulthood, oligodendrocytes add myelin internodes to glutamatergic projection neurons and GABAergic inhibitory neurons. In addition to directing node of Ranvier formation, to enable saltatory conduction and influence action potential transit time, oligodendrocytes support axon health by communicating with axons via the periaxonal space and providing metabolic support that is particularly critical for healthy ageing. In this review we outline the timing of oligodendrogenesis in the developing mouse and human cortex and describe the important role that oligodendrocytes play in sustaining and modulating neuronal function. We also provide insight into the known and speculative impact that myelination has on cortical axons and their associated circuits during the developmental critical periods and throughout life, particularly highlighting their life-long role in learning and remembering.

Item Details

Item Type:Refereed Article
Keywords:cortex, development, myelin, oligodendrocyte, cognition
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Fletcher, JL (Dr Jessica Fletcher)
UTAS Author:Makowiecki, K (Dr Kalina Makowiecki)
UTAS Author:Cullen, CL (Dr Carlie Cullen)
UTAS Author:Young, KM (Professor Kaylene Young)
ID Code:144735
Year Published:2021
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-06-07
Last Modified:2022-08-23

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