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Determinants of infant adiposity across the first 6 months of life: Evidence from the Baby-bod study


Herath, MP and Ahuja, KDK and Beckett, JM and Jayasinghe, S and Byrne, NM and Hills, AP, Determinants of infant adiposity across the first 6 months of life: Evidence from the Baby-bod study, Journal of Clinical Medicine, 10, (8) pp. 1-14. ISSN 2077-0383 (2021) [Refereed Article]

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DOI: doi:10.3390/jcm10081770


Excess adiposity in infancy may predispose individuals to obesity later in life. The literature on determinants of adiposity in infants is equivocal. In this longitudinal cohort study, we investigated pre-pregnancy, prenatal and postnatal determinants of different adiposity indices in infants, i.e., fat mass (FM), percent FM (%FM), fat mass index (FMI) and log-log index (FM/FFMp ), from birth to 6 months, using linear mixed-effects regression. Body composition was measured in 322, 174 and 109 infants at birth and 3 and 6 months afterwards, respectively, utilising air displacement plethysmography. Positive associations were observed between gestation length and infant FM, maternal self-reported pre-pregnancy body mass index and infant %FM, and parity and infant %FM and FMI at birth. Surprisingly, maternal intake of iron supplements during pregnancy was associated with infant FM, %FM and FMI at 3 months and FM/FFMp at 6 months. Male infant sex and formula feeding were negatively associated with all adiposity indices at 6 months. In conclusion, pre-pregnancy and pregnancy factors influence adiposity during early life, and any unfavourable impacts may be modulated postnatally via infant feeding practices. Moreover, as these associations are dependent on the adiposity indices used, it is crucial that researchers use conceptually and statistically robust approaches such as FM/FFMp.

Item Details

Item Type:Refereed Article
Keywords:pre-pregnancy factors, prenatal factors, postnatal factors, infants, fat, adiposity, programming
Research Division:Biomedical and Clinical Sciences
Research Group:Paediatrics
Research Field:Infant and child health
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Overweight and obesity
UTAS Author:Herath, MP (Miss Manoja Herath)
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Beckett, JM (Dr Jeff Beckett)
UTAS Author:Jayasinghe, S (Mr Sisitha Jayasinghe)
UTAS Author:Byrne, NM (Professor Nuala Byrne)
UTAS Author:Hills, AP (Professor Andrew Hills)
ID Code:144682
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Office of the School of Health Sciences
Deposited On:2021-06-04
Last Modified:2021-06-04

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