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Sleep and fear conditioning, extinction learning and extinction recall: a systematic review and meta-analysis of polysomnographic findings

Citation

Schenker, MT and Ney, LJ and Miller, LN and Felmingham, KL and Nicholas, CL and Jordan, AS, Sleep and fear conditioning, extinction learning and extinction recall: a systematic review and meta-analysis of polysomnographic findings, Sleep Medicine Reviews ISSN 1087-0792 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.smrv.2021.101501

Abstract

Sleep may contribute to the long-lasting consolidation and processing of emotional memories. Experimental fear conditioning and extinction paradigms model the development, maintenance, and treatment of anxiety disorders. The literature provides compelling evidence for the involvement of rapid eye movement (REM) sleep in the consolidation of such memories. This meta-analysis correlated polysomnographic sleep findings with psychophysiological reactivity to the danger (CS+) and safety stimuli (CS-), to clarify the specific role of sleep stages before and after fear conditioning, extinction learning and extinction recall. Overall, there was evidence that more pre-learning sleep stage 2 and less slow wave sleep was associated with higher psychophysiological reactivity to the safety stimulus during extinction learning. Preliminary evidence found here support the role of REM sleep during the post-extinction consolidation sleep phase in clinical populations with disrupted sleep, but not in healthy controls. Furthermore, the meta-regressions found that sex moderated the associations between sleep and psychophysiological reactivity throughout the paradigm providing evidence for diverging correlations in male and females. Specifically, increased post-extinction REM was associated with poorer extinction and safety recall in females while the opposite was found in males. These results have implications for future research in the role of sleep in emotional memory processing.

Item Details

Item Type:Refereed Article
Keywords:fear conditioning, fear extinction, sleep, REM, PTSD
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Ney, LJ (Mr Luke Ney)
ID Code:144354
Year Published:2021
Web of Science® Times Cited:2
Deposited By:Psychology
Deposited On:2021-05-17
Last Modified:2021-09-02
Downloads:0

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