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A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

Citation

Ahmadi, S and Wang, S and Nagpal, R and Wang, B and Jain, S and Razazan, A and Mishra, SP and Zhu, X and Wang, Z and Kavanagh, K and Yadav, H, A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis, JCI Insight, 5, (9) pp. 1-18. ISSN 2379-3708 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 American Society for Clinical Investigation

DOI: doi:10.1172/jci.insight.132055

Abstract

Inflammation is a major risk factor of morbidity and mortality in older adults. Although its precise etiology is unknown, low-grade inflammation in older adults is commonly associated with increased intestinal epithelial permeability (leaky gut) and abnormal (dysbiotic) gut microbiota. The increasing older population and lack of treatments to reduce aging-related microbiota dysbiosis, leaky gut, and inflammation culminates in a rise in aging-related comorbidities, constituting a significant public health concern. Here, we demonstrate that a human-origin probiotic cocktail containing 5 Lactobacillus and 5 Enterococcus strains isolated from healthy infant gut prevented high-fat diet–induced (HFD-induced) microbiota dysbiosis, leaky gut, inflammation, metabolic dysfunctions, and physical function decline in older mice. Probiotic-modulated gut microbiota primarily reduced leaky gut by increasing tight junctions, which in turn reduced inflammation. Mechanistically, probiotics modulated microbiota in a way to increase bile salt hydrolase activity, which in turn increased taurine abundance in the gut that stimulated tight junctions and suppressed gut leakiness. Furthermore, in Caenorhabditis elegans, taurine increased life span, reduced adiposity and leaky gut, and enhanced physical function. The results suggest that such probiotic therapies could prevent or treat aging-related leaky gut and inflammation in the elderly.

Item Details

Item Type:Refereed Article
Keywords:gastroenterology, glucose metabolism, innate immunity, macrophages, microbiology
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Gastroenterology and hepatology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Kavanagh, K (Associate Professor Kylie Kavanagh)
ID Code:144333
Year Published:2020
Web of Science® Times Cited:28
Deposited By:Medicine
Deposited On:2021-05-14
Last Modified:2021-10-25
Downloads:0

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