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Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches

Citation

Cosgrone, J and Hinder, MR and St George, RJ and Picardi, C and Smith, SL and Lones, MA and Jamieson, S and Alty, JE, Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches, Neuropsychologia, 157 Article 107885. ISSN 0028-3932 (2021) [Refereed Article]

Copyright Statement

© 2021 Elsevier Ltd. All rights reserved.

DOI: doi:10.1016/j.neuropsychologia.2021.107885

Abstract

While upper limb reaches are often made in a feed-forward manner, visual feedback during the movement can be used to guide the reaching hand towards a target. In Parkinson’s disease (PD), there is evidence that the utilisation of this visual feedback is increased. However, it is unclear if this is due solely to the characteristic slowness of movements in PD providing more opportunity for incorporating visual feedback to modify reach trajectories, or whether it is due to cognitive decline impacting (feed-forward) movement planning ability. To investigate this, we compared reaction times and movement times of reaches to a target in groups of PD patients with normal cognition (PD-NC), mild cognitive impairment (PD-MCI) or dementia (PD-D), to that of controls with normal cognition (CON-NC) or mild cognitive impairment (CON-MCI). Reaches were undertaken with full visual feedback (at a ‘natural’ and ‘fast-as-possible’ pace); with reduced visual feedback of the reaching limb to an illuminated target; and without any visual feedback to a remembered target with eyes closed.

The PD-D group exhibited slower reaction times than all other groups across conditions, indicative of less efficient movement planning. When reaching to a remembered target with eyes closed, all PD groups exhibited slower movement times relative to their natural pace with full visual feedback. Crucially, this relative slowing was most pronounced for the PD-D group, compared to the PD-MCI and PD-NC groups, suggesting that substantial cognitive decline in PD exacerbates dependence on visual feedback during upper limb reaches.

Item Details

Item Type:Refereed Article
Keywords:Parkinson's, dementia, cognitive impairment, motor control, reaching
Research Division:Psychology
Research Group:Biological psychology
Research Field:Cognitive neuroscience
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Hinder, MR (Associate Professor Mark Hinder)
UTAS Author:St George, RJ (Dr Rebecca St George)
UTAS Author:Alty, JE (Associate Professor Jane Alty)
ID Code:144308
Year Published:2021
Web of Science® Times Cited:1
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-05-11
Last Modified:2021-09-16
Downloads:0

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