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The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders


Chong, WC and Shastri, MD and Peterson, GM and Patel, RP and Pathinayake, PS and Dua, K and Hansbro, NG and Hsu, AC and Wark, PA and Shukla, SD and Johansen, MD and Schroder, K and Hansbro, PM, The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders, Clinical & Translational Immunology, 10 Article e1247. ISSN 2050-0068 (2021) [Refereed Article]


Copyright Statement

Copyright 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution‐ NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

DOI: doi:10.1002/cti2.1247


Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome‐induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress‐ and inflammasome‐related inflammatory disorders.

Item Details

Item Type:Refereed Article
Keywords:endoplasmic reticulum stress, inflammasome,inflammatory disorder, NLRP3
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Efficacy of medications
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:144194
Year Published:2021
Web of Science® Times Cited:16
Deposited By:Pharmacy
Deposited On:2021-04-27
Last Modified:2021-06-30
Downloads:5 View Download Statistics

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