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Cognitive impairment in Parkinsonís disease


Cosgrove, J and Alty, JE and Jamieson, S, Cognitive impairment in Parkinson's disease, Postgraduate Medical Journal, 91, (1074) pp. 212-220. ISSN 0032-5473 (2015) [Refereed Article]

Official URL:

DOI: doi:10.1136/postgradmedj-2015-133247


Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). Longitudinal cohort studies have demonstrated that approximately 50% of those with PD develop dementia after 10 years, increasing to over 80% after 20 years. Deficits in cognition can be identified at the time of PD diagnosis in some patients and this mild cognitive impairment (PD-MCI) has been studied extensively over the last decade. Although PD-MCI is a risk factor for developing Parkinson's disease dementia there is evidence to suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses. The major pathological correlate of Parkinson's disease dementia is Lewy body deposition in the limbic system and neocortex although Alzheimer's related pathology is also an important contributor. Pathological damage causes alteration to neurotransmitter systems within the brain, producing behavioural change. Management of cognitive impairment in PD requires a multidisciplinary approach and accurate communication with patients and relatives is essential.

Item Details

Item Type:Refereed Article
Keywords:Parkinson's, dementia, cognitive impairment
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Alty, JE (Associate Professor Jane Alty)
ID Code:144189
Year Published:2015
Web of Science® Times Cited:39
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-04-27
Last Modified:2021-09-21

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