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Computational approaches for understanding the diagnosis and treatment of Parkinson's disease
journal contribution
posted on 2023-05-20, 23:05 authored by Smith, SL, Lones, MA, Bedder, M, Jane AltyJane Alty, Cosgrone, J, Maguire, RJ, Pownall, ME, Ivanoui, D, Lyle, C, Cording, A, Elliott, CJHThis study describes how the application of evolutionary algorithms (EAs) can be used to study motor function in humans with Parkinson's disease (PD) and in animal models of PD. Human data is obtained using commercially available sensors via a range of non-invasive procedures that follow conventional clinical practice. EAs can then be used to classify human data for a range of uses, including diagnosis and disease monitoring. New results are presented that demonstrate how EAs can also be used to classify fruit flies with and without genetic mutations that cause Parkinson's by using measurements of the proboscis extension reflex. The case is made for a computational approach that can be applied across human and animal studies of PD and lays the way for evaluation of existing and new drug therapies in a truly objective way.
History
Publication title
IET Systems BiologyVolume
9Issue
6Pagination
226-233ISSN
1751-8849Department/School
Wicking Dementia Research Education CentrePublisher
The Institution of Engineering and TechnologyPlace of publication
United KingdomRights statement
Copyright 2015 The Institution of Engineering and TechnologyRepository Status
- Restricted