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What to do when people with Parkinsonís disease cannot take their usual oral medications


Alty, J and Robson, J and Duggan-Carter, P and Jamieson, S, What to do when people with Parkinson's disease cannot take their usual oral medications, Practical Neurology, 16, (2) pp. 122-128. ISSN 1474-7758 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 The Authors

DOI: doi:10.1136/practneurol-2015-001267


People with Parkinsonís disease have limited brain reserves of endogenous dopamine; thus, their medications must not be omitted or delayed as this may lead to a significant drop in brain dopamine levels. This has two main clinical consequences: first, a deterioration in disease control, with distressing symptoms such as tremor, pain, rigidity, dysphagia and immobility, and second, an increased risk of developing the life-threatening complication of neuroleptic malignant-like syndrome. Common reasons for people with Parkinsonís disease being unable to take their oral medications are neurogenic dysphagia from progressive disease or concurrent illness, gastroenteritis, iatrogenic Ďnil by mouthí status especially perioperatively, and impaired consciousness level. Here we outline alternative methods to give dopaminergic drugs in the acute setting to people with Parkinsonís disease who cannot take their usual oral treatment, namely using dispersible preparations in thickened fluids, an enteral tube, a transdermal patch or subcutaneous injections.

Item Details

Item Type:Refereed Article
Keywords:Parkinson's, medical management, safety, pharmacology
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Alty, J (Associate Professor Jane Alty)
ID Code:144187
Year Published:2016
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-04-27
Last Modified:2021-09-21

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