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Ten-Year trends in the use of oral anticoagulants in Australian general practice patients with atrial fibrillation
Citation
Bezabhe, WM and Bereznicki, LR and Radford, J and Wimmer, BC and Curtain, C and Salahudeen, MS and Peterson, GM, Ten-Year trends in the use of oral anticoagulants in Australian general practice patients with atrial fibrillation, Frontiers in Pharmacology, 12 Article 586370. ISSN 1663-9812 (2021) [Refereed Article]
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Copyright Statement
Copyright 2021 Bezabhe, Bereznicki, Radford, Wimmer, Curtain, Salahudeen and Peterson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
DOI: doi:10.3389/fphar.2021.586370
Abstract
Objective: Appropriate use of oral anticoagulants (OACs) reduces the risk of stroke in patients with atrial fibrillation (AF). The study characterized the prescribing of OACs in
people with AF in the Australian primary care setting over 10 years.
Design: Retrospective population study.
Setting and Participants: We performed 10 sequential cross-sectional analyses of
patients with a recorded diagnosis of AF between 2009 and 2018 using national general
practice data. The proportion of patients with AF who were prescribed an OAC based on
their stroke risk was examined.
Primary and secondary outcomes: The primary outcome was the proportion of high
stroke risk patients who were prescribed an OAC over a decade. The secondary outcome
was variation in OAC prescribing among general practices.
Results: The sample size of patients with AF ranged from 9,874 in 2009 to 41,751 in 2018.
The proportion who were prescribed an OAC increased from 39.5% (95% CI 38.6–40.5%)
in 2009 to 52.0% (95% CI 51.5–52.4%) in 2018 (p for trend < 0.001). During this time, the
proportion of patients with AF and high stroke risk who were prescribed an OAC rose from
41.7% (95% CI 40.7–42.8%) to 55.2% (95% CI 54.7–55.8%; p for trend < 0.001) with the
direct-acting oral anticoagulants accounting for over three-quarters of usage by 2018.
There was substantial variation in OAC prescribing between general practices. In 2018, the
proportion of moderate to high stroke risk patients who were prescribed an OAC was
38.6% (95% CI 37.2–40.1%) in the lowest practice site quintiles and 65.6% (95% CI
64.5–66.7%) in the highest practice site quintiles.
Conclusions: Over the 10 years, OAC prescribing in high stroke risk patients with AF
increased by one-third. There was considerable variation in OAC prescribing between
general practices.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | trends, anticoagulants, atrial fibrillation, general practice, primary care, Australia |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Pharmacology and pharmaceutical sciences |
| Research Field: | Clinical pharmacology and therapeutics |
| Objective Division: | Health |
| Objective Group: | Provision of health and support services |
| Objective Field: | Provision of health and support services not elsewhere classified |
| UTAS Author: | Bezabhe, WM (Dr Woldesellassie Bezabhe) |
| UTAS Author: | Bereznicki, LR (Professor Luke Bereznicki) |
| UTAS Author: | Radford, J (Professor Jan Radford) |
| UTAS Author: | Wimmer, BC (Dr Barbara Wimmer) |
| UTAS Author: | Curtain, C (Mr Colin Curtain) |
| UTAS Author: | Salahudeen, MS (Dr Mohammed Salahudeen) |
| UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
| ID Code: | 144183 |
| Year Published: | 2021 |
| Web of Science® Times Cited: | 4 |
| Deposited By: | Pharmacy |
| Deposited On: | 2021-04-27 |
| Last Modified: | 2021-06-23 |
| Downloads: | 8 View Download Statistics |
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