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Cognitive deficits in Parkinsonís disease: current perspectives

Citation

Cosgrove, J and Alty, JE, Cognitive deficits in Parkinson's disease: current perspectives, Journal of Parkinsonism and Restless Legs Syndrome, 8 pp. 1-11. ISSN 1927-7725 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 Cosgrove and Alty. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/

DOI: doi:10.2147/JPRLS.S125064

Abstract

Cognitive dysfunction is a common and significant non-motor symptom of Parkinsonís disease (PD). PD mild cognitive impairment (PD-MCI) is evident in approximately one-quarter of patients at the time of PD diagnosis, and half of PD patients have progressed to PD dementia (PDD) after 10 years. The transition to PDD from PD-MCI is not linear and may depend on the facets of cognition affected. Despite increased understanding of pathological, neurotransmitter and genetic drivers, there are no proven pharmacological treatments for PDMCI and those licensed for PDD are of modest benefit only. Biomarkers to predict those most at risk of developing PDD are under investigation and are likely to be essential so that early and individualized treatment can be provided.

Item Details

Item Type:Refereed Article
Keywords:parkinson's disease, dementia, mild cognitive impairment
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Alty, JE (Associate Professor Jane Alty)
ID Code:144180
Year Published:2018
Web of Science® Times Cited:1
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2021-04-27
Last Modified:2021-10-28
Downloads:10 View Download Statistics

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