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The non-specific and sex-differential effects of vaccines


Aaby, P and Benn, CS and Flanagan, Katie and Klein, SL and Kollmann, TR and Lynn, DJ and Shann, F, The non-specific and sex-differential effects of vaccines, Nature Reviews Immunology, 20 pp. 464-470. ISSN 1474-1733 (2020) [Letter or Note in Journal]

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The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the same pathogen. However, evidence accumulated over the past few decades increasingly suggests that vaccines can also have non-specific effects on unrelated infections and diseases, with important implications for childhood mortality particularly in low-income settings. Furthermore, many of these non-specific effects, as well as the pathogen-specific effects, of vaccines show differences between the sexes. Here, members of the Optimmunize consortium discuss the evidence for and potential mechanisms of non-specific and sex-differential effects of vaccines, as well as their potential policy implications. Given that the non-specific effects of some vaccines are now being tested for their ability to protect against COVID-19, the authors also comment on the broader implications of these trials.

Item Details

Item Type:Letter or Note in Journal
Keywords:vaccine, non-specific effects
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Flanagan, Katie (Dr Katie Flanagan)
ID Code:144134
Year Published:2020
Deposited By:UTAS Centre for Rural Health
Deposited On:2021-04-22
Last Modified:2021-04-22

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