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Effect of one-week oral or inhaled salbutamol treatment with washout on repeated sprint performance in trained subjects

Citation

Eibye, K and Jacobson, GA and Bengtsen, K and Jessen, S and Backer, V and Bangsbo, J and Hostrup, M, Effect of one-week oral or inhaled salbutamol treatment with washout on repeated sprint performance in trained subjects, Translational Sports Medicine, 4 pp. 241-249. ISSN 2573-8488 (2021) [Refereed Article]

Copyright Statement

Copyright 2020 John Wiley & Sons Ltd

DOI: doi:10.1002/tsm2.210

Abstract

Background:

Acute and chronic supratherapeutic treatment with the commonly used beta2-agonist salbutamol has the potential to enhance sprint performance and muscle strength. However, little is known about the performance effects of short-term daily permitted inhaled treatment vs oral prohibited treatment in accordance with the 2020 Prohibited List issued by the World Anti-Doping Agency (WADA).

Methods:

Herein, we investigated the effect of twice-daily treatment with 400 μg inhaled or 4 mg oral salbutamol for 1 week on repeated sprint performance in 19 healthy well-trained men and women utilizing a randomized open-label crossover design. Before and after each treatment period, and a 12-16 hours washout to avoid an acute effect of salbutamol, subjects performed a repeated sprint test (3 30-second Wingate).

Results:

Neither oral nor inhaled salbutamol enhanced peak power (oral; 3.0 W; 95% CI −6.8 to 12.8 W; and inhaled; −3.8 W; 95% CI −14.3 to 6.8 W) or mean power (oral; −2.1 W; 95% CI −4.7 to 8.9 W and inhaled; −1.6 W; 95% CI −5.6 to 8.9 W) during the repeated sprint test irrespective of gender.

Conclusions:

These findings indicate that 1 week is insufficient for salbutamol to induce any relevant effect on repeated sprint performance in trained individuals.

Item Details

Item Type:Refereed Article
Keywords:beta2-agonist, muscle doping
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Culture and Society
Objective Group:Sport, exercise and recreation
Objective Field:Sport, exercise and recreation not elsewhere classified
UTAS Author:Jacobson, GA (Professor Glenn Jacobson)
ID Code:144002
Year Published:2021
Deposited By:Pharmacy
Deposited On:2021-04-14
Last Modified:2021-06-18
Downloads:0

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