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Multimaterial 3D printed fluidic device for measuring pharmaceuticals in biological fluids

Citation

Li, F and Macdonald, NP and Guijt, RM and Breadmore, MC, Multimaterial 3D printed fluidic device for measuring pharmaceuticals in biological fluids, Analytical Chemistry, 91, (3) pp. 1758-1763. ISSN 0003-2700 (2019) [Refereed Article]

Copyright Statement

Copyright 2018 American Chemical Society

DOI: doi:10.1021/acs.analchem.8b03772

Abstract

Multimaterial 3D printing provides a unique capability for the creation of highly complex integrated devices where complementary functionality is realized using differences in material properties. Using a single and automated print process, microfluidic devices were fabricated containing (i) an optically transparent structure for fluorescence detection, (ii) electrodes for electrokinetic transport, (iii) a primary membrane to remove particulates and macromolecules including proteins, and (iv) a secondary membrane to concentrate small molecule targets. The device was used for the simultaneous extraction and concentration of small molecule pharmaceuticals from urine, which was followed by an on-chip electrophoretic separation of the concentrated targets for quantitative analysis. Owing to the high level of functional integration inside the device, manual handling was minimal and restricted to the introduction of the sample and buffer solutions. The 3D printed sample-in/answer-out device allowed the direct quantification of ampicillin - a small molecule pharmaceutical - in untreated urine within 3 min, down to 2 ppm. These results demonstrate the potential of 3D printing for on-demand fabrication of disposable, functionally integrated devices for low-cost point-of-collection (POC) diagnostics.

Item Details

Item Type:Refereed Article
Keywords:analytical chemistry
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Li, F (Mr Feng Li)
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:143951
Year Published:2019
Funding Support:Australian Research Council (FT130100101)
Web of Science® Times Cited:32
Deposited By:Chemistry
Deposited On:2021-04-12
Last Modified:2021-05-04
Downloads:0

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