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Multidimensional liquid-phase separations combining both chromatography and electrophoresis - A review


Ranjbar, L and Foley, JP and Breadmore, MC, Multidimensional liquid-phase separations combining both chromatography and electrophoresis - A review, Analytica Chimica Acta, 950 pp. 7-31. ISSN 0003-2670 (2017) [Refereed Article]

Copyright Statement

Copyright 2016 Elsevier B.V.

DOI: doi:10.1016/j.aca.2016.10.025


Described as intrinsically powerful building blocks for two-dimensional separations by Giddings [Anal. Chem., 56 (1984) 1258A1270A], the coupling of chromatography and electrophoresis has been proven to enhance the resolution of a wide array of molecules in complex biological, environmental and food samples. This review provides a comprehensive overview of multidimensional chromato-electrophoretic (LC - E) and electrophero-chromatographic (E - LC) separation systems from inception to the most recent published examples. LC separation modes include reversed phase, ion exchange, and size exclusion. Electromigration separation modes include capillary, microchip or free flow electrophoresis; micellar electrokinetic chromatography; electrochromatography; and isoelectric focusing. The advantages and disadvantages of various non-gel based off-line and on-line hyphenation technologies of LC - E and E - LC are discussed, with conditions and system characteristics also provided.

Item Details

Item Type:Refereed Article
Keywords:chromatography, electrophoresis, two-dimensional liquid chromatography electrophoresis, two-dimensional electrophoresis-liquid chromatography, comprehensive, heart-cutting, analytical chemistry
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Ranjbar, L (Ms Leila Ranjbar Shourabi)
UTAS Author:Foley, JP (Professor Joe Foley)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:143943
Year Published:2017
Funding Support:Australian Research Council (DP0984745)
Web of Science® Times Cited:28
Deposited By:Chemistry
Deposited On:2021-04-12
Last Modified:2022-08-23

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