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The impact of 'cluster maintenance TMS' on irritability occurring in major depressive disorder


Pridmore, S and Turnier-Shea, Y and Erger, S and May, T, The impact of 'cluster maintenance TMS' on irritability occurring in major depressive disorder, Australasian Psychiatry, 29, (2) pp. 222-225. ISSN 1039-8562 (2021) [Refereed Article]

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Copyright 2020 The Royal Australian and New Zealand College of Psychiatrists

DOI: doi:10.1177/1039856220943033


Objective: To determine the impact of clustered maintenance transcranial magnetic stimulation (TMS) on irritability occurring in treatment-resistant major depressive disorder (MDD).

Method: A naturalistic study of 106 courses that includes pre- and posttreatment assessments of subjective and objective depression and a subjective measure of irritability developed for this study.

Results: Forty-six participants (35 females), mean age 43.2 years (14.3), completed 106 courses. There was a significant reduction in irritability and depression scores (p < .001). The change in irritability scores was significantly correlated with the change in depression scores, r = .40, p < .001.

Conclusion: TMS has the capacity to reduce the irritability co-occurring with treatment-resistant MDD, known to be responsive to TMS. This increases the possibility of using TMS in the treatment of irritability co-occurring with other disorders or standing alone (should irritability be categorized as a stand-alone disorder).

Item Details

Item Type:Refereed Article
Keywords:irritability, major depressive disorder, transcranial magnetic stimulation
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Psychiatry (incl. psychotherapy)
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Pridmore, S (Professor Saxby Pridmore)
ID Code:143879
Year Published:2021
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2021-04-08
Last Modified:2021-05-24

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