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The essential role of DSMBs in ensuring the ethics of global vaccine trials to address COVID-19


Eckstein, L and Rid, A and Kamuya, D and Shah, SK, The essential role of DSMBs in ensuring the ethics of global vaccine trials to address COVID-19, Clinical Infectious Diseases pp. 1-16. ISSN 1537-6591 (2021) [Refereed Article]


Copyright Statement

The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1093/cid/ciab239


COVID-19 vaccines are being developed and implemented with unprecedented speed. Accordingly, trials considered ethical at their inception may quickly become concerning. We provide recommendations for Data and Safety Monitoring Boards (DSMBs) on monitoring the ethical acceptability of COVID-19 vaccine trials, focusing on placebo-controlled trials in low- and middle-income countries.

Item Details

Item Type:Refereed Article
Keywords:SARS-CoV-2, COVID-19 vaccines, clinical trials data monitoring committees, standard of care, ethics, research
Research Division:Philosophy and Religious Studies
Research Group:Applied ethics
Research Field:Bioethics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Eckstein, L (Dr Lisa Eckstein)
ID Code:143840
Year Published:2021
Web of Science® Times Cited:5
Deposited By:Office of the Faculty of Law
Deposited On:2021-04-07
Last Modified:2021-05-20
Downloads:8 View Download Statistics

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