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Sleep disturbance and bone mineral density, risk of falls and fracture: Results from a 10.7-year prospective cohort study


Pan, F and Tian, J and Cicuttini, F and Jones, G, Sleep disturbance and bone mineral density, risk of falls and fracture: Results from a 10.7-year prospective cohort study, Bone, 147 pp. 1-6. ISSN 1873-2763 (2021) [Refereed Article]

Copyright Statement

2021 Elsevier Inc.

DOI: doi:10.1016/j.bone.2021.115938


Sleep problems are common in the general population and have been linked to bone health, falls risk and fracture. However, longitudinal studies on sleep-bone health outcomes are lacking and no study has investigated whether an increased risk of fracture is attributable to sleep-related low bone mineral density (BMD) and an increased risk of falls. This study was designed to examine the associations of sleep disturbance with bone mineral density (BMD), risk of falls and fractures over 10.7 years. The analyses were performed in a population-based cohort study with 1099 participants (mean age 62.9 years) enrolled at baseline, and 875, 768 and 563 participants traced at a mean follow-up of 2.6, 5.1 and 10.7 years, respectively. At each visit, self-reported sleep disturbance was recorded. BMD (by dual-energy x-ray absorptiometry), falls risk score and fracture were measured at each visit. The short-form Physiological Profile Assessment was used to measure falls risk score expressed as Z-score. Fractures were self-reported. Mixed-effects model and generalized estimating equations were used for the analyses. In multivariable analysis, there was a dose-response relationship between the extent of sleep disturbance and falls risk score with the strongest association in those reporting the worst sleep disturbance (β = 0.15/unit; 95%CI 0.02-0.28). The worst sleep disturbance was associated with an increased risk of any (relative risk [RR] 1.30/unit; 95%CI 1.01-1.67) and vertebral fracture (RR 2.41/unit; 95%CI 1.00-5.80) compared with those reporting no interrupted sleep. Women but not men with sleep disturbance had a higher risk of vertebral fracture (RR: 2.07 to 6.02, P < 0.05). These were independent of covariates, hip BMD and falls risk. There was no statistically significant association between sleep disturbance and BMD at the hip, spine or total body. Sleep disturbance was independently associated with a greater falls risk score and an increased risk of fractures. Further research is needed to confirm and identify underlying mechanisms for these associations.

Item Details

Item Type:Refereed Article
Keywords:sleep, bone mineral density, falls, fractures, risk
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Tian, J (Dr Jing Tian)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:143734
Year Published:2021
Funding Support:National Health and Medical Research Council (1157535)
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-03-31
Last Modified:2021-05-03

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