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TAK1 signaling is a potential therapeutic target for pathological angiogenesis
Citation
Zhu, L and Lama, S and Tu, L and Dusting, GJ and Wang, J-H and Liu, G, TAK1 signaling is a potential therapeutic target for pathological angiogenesis, Angiogenesis ISSN 0969-6970 (2021) [Refereed Article]
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Copyright Statement
© The Author(s), under exclusive licence to Springer Nature B.V. 2021. Post-prints are subject to Springer Nature re-use terms
DOI: doi:10.1007/s10456-021-09787-5
Abstract
Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can
promote neoplastic diseases and retinopathies, while inadequate angiogenesis can lead to aberrant perfusion and impaired
wound healing. Transforming growth factor β activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase
kinase kinase family, is a key modulator involved in a range of cellular functions including the immune responses, cell survival and death. TAK1 is activated in response to various stimuli such as proinfammatory cytokines, hypoxia, and oxidative
stress. Emerging evidence has recently suggested that TAK1 is intimately involved in angiogenesis and mediates pathogenic
processes related to angiogenesis. Several detailed mechanisms by which TAK1 regulates pathological angiogenesis have
been clarifed, and potential therapeutics targeting TAK1 have emerged. In this review, we summarize recent studies of TAK1
in angiogenesis and discuss the crosstalk between TAK1 and signaling pathways involved in pathological angiogenesis.
We also discuss the approaches for selectively targeting TAK1 and highlight the rationales of therapeutic strategies based
onTAK1 inhibition for the treatment of pathological angiogenesis.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | transforming growth factor β activated kinase 1, angiogenesis, infammation, hypoxia, oxidative stress |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Ophthalmology and optometry |
| Research Field: | Ophthalmology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Treatment of human diseases and conditions |
| UTAS Author: | Zhu, L (Ms Linxin Zhu) |
| UTAS Author: | Lama, S (Mr Suraj Lama) |
| UTAS Author: | Liu, G (Associate Professor Guei-Sheung Liu) |
| ID Code: | 143642 |
| Year Published: | 2021 |
| Funding Support: | National Health and Medical Research Council (1185600) |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2021-03-29 |
| Last Modified: | 2021-06-02 |
| Downloads: | 3 View Download Statistics |
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