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TAK1 signaling is a potential therapeutic target for pathological angiogenesis


Zhu, L and Lama, S and Tu, L and Dusting, GJ and Wang, J-H and Liu, G, TAK1 signaling is a potential therapeutic target for pathological angiogenesis, Angiogenesis ISSN 0969-6970 (2021) [Refereed Article]

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The Author(s), under exclusive licence to Springer Nature B.V. 2021. Post-prints are subject to Springer Nature re-use terms

DOI: doi:10.1007/s10456-021-09787-5


Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote neoplastic diseases and retinopathies, while inadequate angiogenesis can lead to aberrant perfusion and impaired wound healing. Transforming growth factor β activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase family, is a key modulator involved in a range of cellular functions including the immune responses, cell survival and death. TAK1 is activated in response to various stimuli such as proinfammatory cytokines, hypoxia, and oxidative stress. Emerging evidence has recently suggested that TAK1 is intimately involved in angiogenesis and mediates pathogenic processes related to angiogenesis. Several detailed mechanisms by which TAK1 regulates pathological angiogenesis have been clarifed, and potential therapeutics targeting TAK1 have emerged. In this review, we summarize recent studies of TAK1 in angiogenesis and discuss the crosstalk between TAK1 and signaling pathways involved in pathological angiogenesis. We also discuss the approaches for selectively targeting TAK1 and highlight the rationales of therapeutic strategies based onTAK1 inhibition for the treatment of pathological angiogenesis.

Item Details

Item Type:Refereed Article
Keywords:transforming growth factor β activated kinase 1, angiogenesis, infammation, hypoxia, oxidative stress
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Zhu, L (Ms Linxin Zhu)
UTAS Author:Lama, S (Mr Suraj Lama)
UTAS Author:Liu, G (Associate Professor Guei-Sheung Liu)
ID Code:143642
Year Published:2021
Funding Support:National Health and Medical Research Council (1185600)
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-03-29
Last Modified:2021-06-02
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