eCite Digital Repository

Cross-sectional and temporal differences in health-related quality of life of people with and without osteoarthritis: a 10-year prospective study


Zhao, T and Ahmad, H and Winzenberg, T and Aitken, D and de Graaff, B and Jones, G and Palmer, AJ, Cross-sectional and temporal differences in health-related quality of life of people with and without osteoarthritis: a 10-year prospective study, Rheumatology pp. 1-8. ISSN 1462-0324 (2020) [Refereed Article]

Copyright Statement

VC The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

DOI: doi:10.1093/rheumatology/keaa787


Objective: To describe the impact of OA on health-related quality of life (HRQoL) in the forms of health state utilities (HSUs) and health-dimension scores, and to compare the longitudinal changes in HRQoL for people with and without OA, using an Australian population-based longitudinal cohort.

Methods: Participants of the Tasmanian Older Adult Cohort with data on OA diagnosis and HRQoL were included [interviewed at baseline (n 1093), 2.5 years (n 871), 5 years (n 760) and 10 years (n 562)]. HRQoL was assessed using the Assessment of Quality of Life four-dimensions and analysed using multivariable linear mixed regressions.

Results: Compared with participants without OA, HSUs for those with OA were 0.07 (95% confidence interval: 0.09, 0.05) units lower on average over 10 years. HSUs for participants with knee and/or hip OA were similar to those with other types of OA at the 2.5 year follow-up and then diverged, with HSUs of the former being up to 0.09 units lower than the latter. Those with OA had lower scores for psychological wellness, independent living and social relationships compared with those without OA. Independent living and social relationships were mainly impacted by knee and/or hip OA, with the effect on the former increasing over time.

Conclusion: Interventions to improve HRQoL should be tailored to specific OA types, health dimensions, and times. Support for maintaining psychological wellness should be provided, irrespective of OA type and duration. However, support for maintaining independent living could be more relevant to knee and/or hip OA patients living with the disease for longer.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, HRQoL, HSUs, the Assessment of Quality of Life four-dimensions
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Zhao, T (Dr Ting Zhao)
UTAS Author:Ahmad, H (Dr Hasnat Ahmad)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:de Graaff, B (Dr Barbara de Graaff)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:143501
Year Published:2020
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-03-20
Last Modified:2021-06-11

Repository Staff Only: item control page