Black, JA and Campbell, JA and Parker, SC and Sharman, JE and Nelson, MR and Otahal, P and Hamilton, G and Marwick, TH, Absolute risk assessment for guiding cardiovascular risk management in a chest pain clinic, Medical Journal of Australia ISSN 0025-729X (2021) [Refereed Article]
Copyright 2021 AMPCo Pty Ltd
Objectives: To assess the efficacy of a pro-active, absolute cardiovascular risk-guided approach to opportunistically modifying cardiovascular risk factors in patients without coronary ischaemia attending a chest pain clinic.
Design: Prospective, randomised, open label, blinded endpoint study.
Setting: The rapid access chest pain clinic of Royal Hobart Hospital, a tertiary hospital.
Participants: Patients who presented to the chest pain clinic between 1 July 2014 and 31 December 2017 who had intermediate to high absolute cardiovascular risk scores (5-year risk ≥ 8%). Patients with known cardiac disease or from groups with clinically determined high risk of cardiovascular disease were excluded.
Main outcome measures: The primary endpoint was change in 5-year absolute risk score (Australian absolute risk calculator) at follow-up (at least 12 months after baseline assessment). Secondary endpoints were changes in lipid profile, blood pressure, smoking status, and body mass index, and major adverse cardiovascular events.
Results: The mean change in risk at follow-up was +0.4 percentage points (95% CI, -0.8 to 1.5 percentage points) for the 98 control group patients and -2.4 percentage points (95% CI, -1.5 to -3.4 percentage points) for the 91 intervention group patients; the between-group difference in change was 2.7 percentage points (95% CI, 1.2-4.1 percentage points). Mean changes in lipid profile, systolic blood pressure, and smoking status were larger for the intervention group, but not statistically different from those for the control group.
Conclusions: An absolute cardiovascular risk-guided, pro-active risk factor management strategy employed opportunistically in a chest pain clinic significantly improved 5-year absolute cardiovascular risk scores.
|Item Type:||Refereed Article|
|Keywords:||cardiology, rapid access chest pain clinic, quality of life|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Evaluation of health and support services|
|Objective Field:||Evaluation of health outcomes|
|UTAS Author:||Campbell, JA (Dr Julie Campbell)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|UTAS Author:||Nelson, MR (Professor Mark Nelson)|
|UTAS Author:||Otahal, P (Mr Petr Otahal)|
|UTAS Author:||Marwick, TH (Professor Tom Marwick)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page