eCite Digital Repository
Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection
Karupiah, G and Blanden, RV and Ramshaw, IA, Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection, The Journal of Experimental Medicine, 172, (5) pp. 1495-503. ISSN 0022-1007 (1990) [Refereed Article]
|PDF (Published version)|
Copyright 1990 the authors. The Rockefeller University Press.
Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.
|Item Type:||Refereed Article|
|Keywords:||Recombinant vaccinia virus; IL-2; protective immunity; IFN-g-mediated protection|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Innate immunity|
|Objective Group:||Clinical health|
|Objective Field:||Prevention of human diseases and conditions|
|UTAS Author:||Karupiah, G (Associate Professor Guna Karupiah)|
|Web of Science® Times Cited:||115|
|Downloads:||11 View Download Statistics|
Repository Staff Only: item control page