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Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection

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posted on 2023-05-20, 21:06 authored by Gunasegaran KarupiahGunasegaran Karupiah, Blanden, RV, Ramshaw, IA
Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.

History

Publication title

The Journal of Experimental Medicine

Volume

172

Issue

5

Pagination

1495-503

ISSN

0022-1007

Department/School

Tasmanian School of Medicine

Publisher

Rockefeller Univ Press

Place of publication

1114 First Ave, 4Th Fl, New York, USA, Ny, 10021

Rights statement

Copyright 1990 the authors. The Rockefeller University Press.

Repository Status

  • Open

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

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