Preview

PDF (Published version) 874Kb

Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.

Item Type:	Refereed Article
Keywords:	Recombinant vaccinia virus; IL-2; protective immunity; IFN-g-mediated protection
Research Division:	Biomedical and Clinical Sciences
Research Group:	Immunology
Research Field:	Innate immunity
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Prevention of human diseases and conditions
UTAS Author:	Karupiah, G (Associate Professor Guna Karupiah)
ID Code:	142865
Year Published:	1990
Web of Science® Times Cited:	115
Deposited By:	Medicine
Deposited On:	2021-02-12
Last Modified:	2021-05-27
Downloads:	11 View Download Statistics