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Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2


Karupiah, G and Coupar, B and Ramshaw, I and Boyle, D and Blanden, R and Andrew, M, Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2, Immunology and Cell Biology, 68, (Pt 5) pp. 325-333. ISSN 0818-9641 (1990) [Refereed Article]

Copyright Statement

Copyright 2010 Australasian Society for Immunology Inc.

DOI: doi:10.1038/icb.1990.44


Vaccinia virus was shown to replicate in the ovaries of normal inbred mice and cause sufficient damage to ovarian follicles to decrease fertility of the mice. The mouse-adapted strain, VV-WR, had a greater affinity for growth in ovaries than the vaccine strains, VV-Elstree, VV-NYBH or VV-Copenhagen. Virus reached the ovaries after intravenous or intraperitoneal inoculation, but not after subcutaneous inoculation in the foot pad. Interleukin-2 (IL-2), when expressed by a recombinant vaccinia virus was able to decrease the titre of virus in the ovaries and prevent infertility. Both non-specific (natural killer cells) and antigen-specific mechanisms were active within the ovaries and may play a role in the IL-2-mediated clearance of vaccinia virus.

Item Details

Item Type:Refereed Article
Keywords:Recombinant vaccinia virus; IL-2; protective immunity; NK cells; ovarian damage
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142864
Year Published:1990
Web of Science® Times Cited:34
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-06-30

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