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Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2


Karupiah, G and Coupar, BE and Andrew, ME and Boyle, DB and Phillips, SM and Mullbacher, A and Blanden, RV and Ramshaw, IA, Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2, Journal of Immunology, 144, (1) pp. 290-8. ISSN 0022-1767 (1990) [Refereed Article]

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Copyright 1990 The American Association of Immunologists

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The role of cytotoxic T cells and NK cells in the recovery of immunodeficient, athymic, nude mice infected with a recombinant vaccinia virus (VV) encoding murine IL-2 was investigated. Kinetic studies with the IL-2-encoding recombinant (VV-HA-IL2) and control (VV-HA-TK) viruses excluded a role for cytotoxic T cells but suggested the possible involvement of NK cells. In athymic nude mice given VV-HA-IL2, NK activity was at least threefold higher than mice infected with VV-HA-TK and this activity persisted for at least 6 days after infection. The effectors mediating the NK-like activity were asialo-GM1+ (as-GM1+), Thy1.2+/-, CD4- and CD8-, the phenotype of conventional NK cells. Elevated NK activity coincided with the rapid clearance of VV-HA-IL2 from ovaries of infected normal CBA/H mice but not from ovaries of CBA beige mice which had no detectable NK activity in spleens or ovaries. The expression of IL-2 in recombinant VV infection probably induces a cascade of immunologic effects of which elevated NK activity is one. We speculate that the chemoattractant and NK activity augmenting effects of IL-2 may contribute to recovery from VV-infection.

Item Details

Item Type:Refereed Article
Keywords:Recombinant vaccinia virus; IL-2; protective immunity; NK cells
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142863
Year Published:1990
Web of Science® Times Cited:108
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-11-16

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