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Effects of vaccinia virus-expressed interleukin 2 on the immune system of sublethally irradiated mice


Andrew, ME and Karupiah, G and Boyle, DB and Blanden, RV and Mullbacher, A and Ramshaw, IA and Coupar, BE, Effects of vaccinia virus-expressed interleukin 2 on the immune system of sublethally irradiated mice, Microbial Pathogenesis, 10, (5) pp. 363-71. ISSN 0882-4010 (1991) [Refereed Article]

Copyright Statement

1991 Academic Press Limited

DOI: doi:10.1016/0882-4010(91)90081-k


Vaccinia virus that expressed interleukin 2 (IL 2) was cleared from immunodeficient irradiated mice more efficiently than virus that did not express interleukin 2. These results extend the previously observed protection from nude mice to another model of immunodeficiency. No antibody or cytotoxic T lymphocyte response could be detected in sublethally irradiated mice that had been inoculated with IL 2-expressing vaccinia virus, but levels of splenic natural killer cell activity were elevated. Sublethally irradiated mice that had recovered from IL 2-plus hemagglutinin-expressing vaccinia virus were partially protected against both influenza virus and vaccinia virus. These results indicate that vaccinia virus-expressed IL 2 mediates clearance of primary viral infection via a mechanism that does not involve antibody or cytotoxic T lymphocytes. They also indicate that inclusion of lymphokine genes in live recombinant viral vaccine vectors may increase vaccine safety.

Item Details

Item Type:Refereed Article
Keywords:Recombinant vaccinia virus; IL-2; protective immunity; gamma irradiation; immunodeficiency
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142862
Year Published:1991
Web of Science® Times Cited:2
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-05-25

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