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Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection
Citation
Karupiah, G and Chen, J-H and Nathan, CF and Mahalingam, S and MacMicking, JD, Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection, Journal of Virology, 79, (2) pp. 7703-7706. ISSN 0022-538X (1998) [Refereed Article]
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DOI: doi:10.1128/JVI.72.9.7703-7706.1998
Abstract
To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Nitric oxide; antiviral immunity; ectromelia virus |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Innate immunity |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Prevention of human diseases and conditions |
| UTAS Author: | Karupiah, G (Associate Professor Guna Karupiah) |
| ID Code: | 142844 |
| Year Published: | 1998 |
| Web of Science® Times Cited: | 48 |
| Deposited By: | Medicine |
| Deposited On: | 2021-02-12 |
| Last Modified: | 2021-02-23 |
| Downloads: | 0 |
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