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Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection
journal contribution
posted on 2023-05-20, 21:03 authored by Gunasegaran KarupiahGunasegaran Karupiah, Chen, J-H, Nathan, CF, Mahalingam, S, MacMicking, JDTo assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.
History
Publication title
Journal of VirologyVolume
79Pagination
7703-7706ISSN
0022-538XDepartment/School
Tasmanian School of MedicinePublisher
Amer Soc MicrobiologyPlace of publication
1752 N St Nw, Washington, USA, Dc, 20036-2904Rights statement
Copyright © 1998, American Society for MicrobiologyRepository Status
- Restricted