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Interferon-inducible chemokines and immunity to poxvirus infections


Mahalingam, S and Foster, PS and Lobigs, M and Farber, JM and Karupiah, G, Interferon-inducible chemokines and immunity to poxvirus infections, Immunological Reviews, 177 pp. 127-33. ISSN 0105-2896 (2000) [Substantial Review]

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DOI: doi:10.1034/j.1600-065x.2000.17720.x


The biological roles of two interferon-inducible chemokines, monokine induced by gamma interferon (Mig) and cytokine responsive gene (Crg-2), in the immune response against vaccinia virus (VV) and ectromelia virus (EV) infections are discussed. To investigate their antiviral effects in vivo, the expression profiles of these chemokines during the course of VV or EV infections were first established. Mig and Crg-2 were induced in multiple organs at high levels early after infection with VV. Both chemokines were rapidly induced in popliteal lymph nodes of C57BL/6 mice but not in BALB/c mice following infection with EV. Secondly, recombinant vaccinia viruses (rVV) encoding Mig or Crg-2 were constructed to investigate the immunobiology of infection in athymic, nude and euthymic, normal mice. Finally, the EV model in combination with recombinant Mig and Crg-2 proteins was used to test their effects on viral replication and immune responses in vivo. The results of these investigations demonstrate that the mechanisms of Mig- and Crg-2-induced viral clearance involve natural killer cells and interferons.

Item Details

Item Type:Substantial Review
Keywords:IFN-g; chemokines; chemotaxis; antiviral immunity; poxviruses
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142835
Year Published:2000
Web of Science® Times Cited:20
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-02

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