eCite Digital Repository
Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses
Belz, GT and Smith, CM and Eichner, D and Shortman, K and Karupiah, G and Carbone, FR and Heath, WR, Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses, Journal of Immunology, 172, (4) pp. 1996-2000. ISSN 0022-1767 (2004) [Refereed Article]
Copyright 2004 The American Association of Immunologists, Inc.
Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
|Item Type:||Refereed Article|
|Keywords:||cytotoxic T cells; dendritic cells; generation of cell-mediated immunity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Cellular immunology|
|Objective Group:||Clinical health|
|Objective Field:||Prevention of human diseases and conditions|
|UTAS Author:||Karupiah, G (Associate Professor Guna Karupiah)|
|Web of Science® Times Cited:||244|
Repository Staff Only: item control page