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Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses
journal contribution
posted on 2023-05-20, 21:01 authored by Belz, GT, Smith, CM, Eichner, D, Shortman, K, Gunasegaran KarupiahGunasegaran Karupiah, Carbone, FR, Heath, WRDendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
History
Publication title
Journal of ImmunologyVolume
172Issue
4Pagination
1996-2000ISSN
0022-1767Department/School
Tasmanian School of MedicinePublisher
Amer Assoc ImmunologistsPlace of publication
9650 Rockville Pike, Bethesda, USA, Md, 20814Rights statement
Copyright 2004 The American Association of Immunologists, Inc.Repository Status
- Restricted