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Interferon function is not required for recovery from a secondary poxvirus infection
Citation
Panchanathan, V and Chaudhri, G and Karupiah, G, Interferon function is not required for recovery from a secondary poxvirus infection, Proceedings of the National Academy of Sciences, 102, (36) pp. 12921-6. ISSN 0027-8424 (2005) [Refereed Article]
Copyright Statement
© 2005 by The National Academy of Sciences of the USA
DOI: doi:10.1073/pnas.0505180102
Abstract
IFN function is critical for recovery from most primary viral infections, including poxvirus infection. In contrast, very little is known
about the requirement for IFN function in mediating recovery from
a secondary virus infection. We have used ectromelia virus (ECTV),
an orthopoxvirus very closely related to variola virus, to investigate the importance of IFN function in recovery from a secondary
infection. Variola virus, the causative agent of smallpox in humans,
and ECTV, which causes mousepox in mice, both encode receptor
homologs that are thought to interfere with host IFN function.
Using a prime–challenge regime, in which avirulent ECTV is used to
prime mice deficient in type III IFN function or IFN regulatory
factor 1 (IRF-1) and then challenging the mice with a virulent strain,
we show that IFN function is redundant for virus clearance during
a secondary ECTV infection. A neutralizing Ab response is generated in a secondary infection, even in the absence of IFN function,
although when present, IFN strongly influences the neutralizing
titer and subtype of IgG that is produced. Importantly, the depletion of CD8 T lymphocytes during a secondary challenge in
IFN-deficient mice does not affect their capacity to clear ECTV,
indicating that Ab is critical for the control of a secondary infection.
Item Details
Item Type: | Refereed Article |
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Keywords: | Poxvirus; Interferon responses; secondary viral infection viral infection |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical microbiology |
Research Field: | Medical virology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Prevention of human diseases and conditions |
UTAS Author: | Karupiah, G (Associate Professor Guna Karupiah) |
ID Code: | 142826 |
Year Published: | 2005 |
Web of Science® Times Cited: | 42 |
Deposited By: | Medicine |
Deposited On: | 2021-02-12 |
Last Modified: | 2021-03-31 |
Downloads: | 0 |
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