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Poxvirus CD8+ T-Cell determinants and cross-reactivity in BALB/c mice

journal contribution
posted on 2023-05-20, 21:00 authored by Tscharke, DC, Woo, W-P, Sakala, IG, Sidney, J, Sette, A, Moss, DJ, Bennink, JR, Gunasegaran KarupiahGunasegaran Karupiah, Yewdell, JW
Mouse models of orthopoxvirus disease provide great promise for probing basic questions regarding host responses to this group of pathogens, which includes the causative agents of monkeypox and smallpox. However, some essential tools for their study that are taken for granted with other mouse models are not available for these viruses. Here we map and characterize the initial CD8+ T-cell determinants for poxviruses in H-2d-haplotype mice. CD8+ T cells recognizing these three determinants make up around 40% of the total responses to vaccinia virus during and after resolution of infection. We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus.

History

Publication title

Journal of Virology

Volume

80

Issue

13

Pagination

6318-6323

ISSN

0022-538X

Department/School

Tasmanian School of Medicine

Publisher

Amer Soc Microbiology

Place of publication

1752 N St Nw, Washington, USA, Dc, 20036-2904

Rights statement

Copyright © 2006, American Society for Microbiology

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

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