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Immunopathogenesis of poxvirus infections: forecasting the impending storm


Stanford, MM and McFadden, G and Karupiah, G and Chaudhri, G, Immunopathogenesis of poxvirus infections: forecasting the impending storm, Immunology and Cell Biology, 85, (2) pp. 93-102. ISSN 0818-9641 (2007) [Substantial Review]

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DOI: doi:10.1038/sj.icb.7100033


Variola virus, the causative agent of smallpox, is a member of the poxvirus family and one of the most virulent human pathogens known. Although smallpox was eradicated almost 30 years ago, it is not understood why the mortality rates associated with the disease were high, why some patients recovered, and what constitutes an effective host response against infection. As variola virus infects only humans, our current understanding of poxvirus infections comes largely from historical clinical data from smallpox patients and from animal studies using closely related viruses such as ectromelia, myxoma and monkeypox. The outcome of an infection is determined by a complex interaction between the type of immune response mounted by the host and by evasion mechanisms that the virus has evolved to subvert it. Disease pathogenesis is also a function of both host and viral factors. Poxviruses are not only cytopathic, causing host tissue damage, but also encode an array of immunomodulatory molecules that affect the severity of disease. The ability of the host to control virus replication is therefore critical in limiting tissue damage. However, in addition to targeting virus, the immune response can inadvertently damage the host to such a degree that it causes illness and even death. There is growing evidence that many of the symptoms associated with serious poxvirus infections are a result of a 'cytokine storm' or sepsis and that this may be the underlying cause of pathology.

Item Details

Item Type:Substantial Review
Keywords:Immunopathology; orthopoxvirus infections; disease; cytokine storms
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical virology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142819
Year Published:2007
Web of Science® Times Cited:61
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-02

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