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T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control

Citation

Chaudhri, G and Quah, BJ and Wang, Y and Tan, AHY and Zhou, J and Karupiah, G and Parish, CR, T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control, National Academy of Sciences of The United States of America. Proceedings, 106, (35) pp. 14984-9. ISSN 0027-8424 (2009) [Refereed Article]

Copyright Statement

Copyright 2020 the authors

DOI: doi:10.1073/pnas.0906554106

Abstract

A remarkable feature of the adaptive immune system is the speed at which small numbers of antigen-specific lymphocytes can mediate a successful immune response. Rapid expansion of T and B lymphocyte clones that have receptors specific for a particular antigen is one of the primary means by which a swift response is generated. Although much of this clonal expansion is caused by the division of antigen-specific cells, here we demonstrate an additional mechanism by which the pool of effector T cells against a viral infection can quickly enlarge. Our data show that virus-specific CD8+ cytotoxic T lymphocytes (CTL) can transfer their T cell receptors (TCR) to recipient CTL of an unrelated specificity that, as a consequence, gain the antigen specificity of the donor T cell. This process occurs within minutes via membrane exchange and results in the recipient CTL acquiring the ability to recognize and eliminate cells targeted by the donor TCR, while still retaining the antigen specificity of its own TCR. Such receptor sharing allows rapid, proliferation-independent expansion of virus-specific T cell clones of low frequency and plays a highly significant antiviral role that can protect the host from an otherwise lethal infection.

Item Details

Item Type:Refereed Article
Keywords:Trogocytosis; antiviral immunity; T cell receptor transfer; poxvirus
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142817
Year Published:2009
Web of Science® Times Cited:22
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-09-22
Downloads:0

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