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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain
Citation
Cullen, CL and Pepper, RE and Clutterbuck, MT and Pitman, KA and Oorschot, V and Auderset, L and Tang, AD and Ramm, G and Emery, B and Rodger, J and Jolivet, RB and Young, KM, Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain, Cell Reports, 34, (3) pp. 1-15. ISSN 2211-1247 (2021) [Refereed Article]
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Copyright Statement
Copyright 2020 The Authors. This is an open access article under the CC BY-NC-ND license
DOI: doi:10.1016/j.celrep.2020.108641
Abstract
Central nervous system myelination increases action potential conduction velocity. However, it is unclear
how myelination is coordinated to ensure the temporally precise arrival of action potentials and facilitate information processing within cortical and associative circuits. Here, we show that myelin sheaths, supported
by mature oligodendrocytes, remain plastic in the adult mouse brain and undergo subtle structural modifications to influence action potential conduction velocity. Repetitive transcranial magnetic stimulation and
spatial learning, two stimuli that modify neuronal activity, alter the length of the nodes of Ranvier and the
size of the periaxonal space within active brain regions. This change in the axon-glial configuration is independent of oligodendrogenesis and robustly alters action potential conduction velocity. Because aptitude
in the spatial learning task was found to correlate with action potential conduction velocity in the fimbriafornix pathway, modifying the axon-glial configuration may be a mechanism that facilitates learning in the
adult mouse brain.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | myelin, nodes of Ranvier, periaxonal space, oligodendrocyte, learning, transcranial magnetic stimulation |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central nervous system |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in the biomedical and clinical sciences |
| UTAS Author: | Cullen, CL (Dr Carlie Cullen) |
| UTAS Author: | Pepper, RE (Miss Renee Pepper) |
| UTAS Author: | Clutterbuck, MT (Mr Mackenzie Clutterbuck) |
| UTAS Author: | Pitman, KA (Ms Kimberley Pitman) |
| UTAS Author: | Auderset, L (Mr Loic Auderset) |
| UTAS Author: | Young, KM (Associate Professor Kaylene Young) |
| ID Code: | 142504 |
| Year Published: | 2021 |
| Funding Support: | Australian Research Council (DP180101494) |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2021-01-20 |
| Last Modified: | 2022-01-07 |
| Downloads: | 8 View Download Statistics |
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