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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Citation

Cullen, CL and Pepper, RE and Clutterbuck, MT and Pitman, KA and Oorschot, V and Auderset, L and Tang, AD and Ramm, G and Emery, B and Rodger, J and Jolivet, RB and Young, KM, Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain, Cell Reports ISSN 2211-1247 (2021) [Refereed Article]


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DOI: doi:10.1016/j.celrep.2020.108641

Abstract

Central nervous system myelination increases action potential conduction velocity. However, it is unclear how myelination is coordinated to ensure the temporally precise arrival of action potentials and facilitate information processing within cortical and associative circuits. Here, we show that myelin sheaths, supported by mature oligodendrocytes, remain plastic in the adult mouse brain and undergo subtle structural modifications to influence action potential conduction velocity. Repetitive transcranial magnetic stimulation and spatial learning, two stimuli that modify neuronal activity, alter the length of the nodes of Ranvier and the size of the periaxonal space within active brain regions. This change in the axon-glial configuration is independent of oligodendrogenesis and robustly alters action potential conduction velocity. Because aptitude in the spatial learning task was found to correlate with action potential conduction velocity in the fimbriafornix pathway, modifying the axon-glial configuration may be a mechanism that facilitates learning in the adult mouse brain.

Item Details

Item Type:Refereed Article
Keywords:myelin, nodes of Ranvier, periaxonal space, oligodendrocyte, learning, transcranial magnetic stimulation
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Cullen, CL (Dr Carlie Cullen)
UTAS Author:Pepper, RE (Miss Renee Pepper)
UTAS Author:Clutterbuck, MT (Mr Mackenzie Clutterbuck)
UTAS Author:Pitman, KA (Ms Kimberley Pitman)
UTAS Author:Auderset, L (Mr Loic Auderset)
UTAS Author:Young, KM (Associate Professor Kaylene Young)
ID Code:142504
Year Published:2021
Funding Support:Australian Research Council (DP180101494)
Deposited By:Menzies Institute for Medical Research
Deposited On:2021-01-20
Last Modified:2021-01-21
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