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Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy

Citation

Kourakis, S and Timpani, CA and de Haan, JB and Gueven, N and Fischer, D and Rybalka, E, Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy, Redox Biology Article 101803. ISSN 2213-2317 (2021) [Refereed Article]


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Copyright Statement

Copyright 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license

DOI: doi:10.1016/j.redox.2020.101803

Abstract

Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at the cellular and molecular level including calcium-mediated muscle degeneration; mitochondrial dysfunction; oxidative stress; inflammation; insufficient muscle regeneration and dysregulated protein and organelle maintenance. Previous investigative therapeutics tended to isolate and focus on just one of these targets and, consequently, therapeutic activity has been limited. Nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor that upregulates many cytoprotective gene products in response to oxidants and other toxic stressors. Unlike other strategies, targeted Nrf2 activation has the potential to simultaneously modulate separate pathological features of DMD to amplify therapeutic benefits. Here, we review the literature providing theoretical context for targeting Nrf2 as a disease modifying treatment against DMD.

Item Details

Item Type:Refereed Article
Keywords:Nrf2, Duchenne Muscular Dystrophy, reactive oxygen species, oxidative stress, skeletal muscle, hormesis
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Gueven, N (Dr Nuri Guven)
ID Code:142410
Year Published:2021
Web of Science® Times Cited:5
Deposited By:Pharmacy
Deposited On:2021-01-14
Last Modified:2021-02-10
Downloads:4 View Download Statistics

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